UNIVERSITY OF VIRGINIA
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        • Acoustic Differential Extraction
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        • Enhanced Sperm Cell Recovery
        • Monolith Stationary Phase for Microfluidic DNA Purification
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        • Infrared PCR
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      • Label-Free Optical Methods for DNA and Cell Quantification
      • DNA Extraction and PCR Amplification
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      • Passive Valving
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      • A Fully Integrated Microfluidic Genetic Analysis Device for the Detection of Blood Cancers
      • Electric Field-Flow Fractionation for DNA Concentration
      • Acousto-Optic Tunable Fiber
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Label-Free Optical Methods for DNA and Cell Quantification 

The novel label-free optical method for DNA and cwll quantification, coined as "pinwheel  assay", is based on the phenomenon that  silica-coated superparamagnetic beads aggregate in the presence of DNA and a rotating magnetic field under chaotropic conditions. This assay requires simple and inexpensive instrumentation, and has proven to be as sensitive as conventional fluorescence methods. The pinwheel assay is being applied in clinical diagnostics, such as  blood analyisis and drug suscptibility testing, etc, which provides a rapid and cost-effective alternative to conventioal techniques. 



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Contact Landers Research Group
jpl5e@virginia.edu
(434) 243-8658
375, 379, 395 Chemistry Building
McCormick Road
​Charlottesville, Va 22904
UVA Chemistry Department
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  • Home
  • Previous Research
    • Centrifugal Microdevices >
      • PET Chips
    • Clinical Diagnostics and Forensic Analysis >
      • Cell Sorting and Solid Phase Extraction >
        • Acoustic Differential Extraction
        • Isolation of Circulating Tumor Cells
        • Enhanced Sperm Cell Recovery
        • Monolith Stationary Phase for Microfluidic DNA Purification
        • Nucleic Acid Purification in a Two-Stage, Dual-Phase Microchip
        • Large Volume Reduction Solid Phase Extraction
        • Plastic SPE Microdevices
      • Polymerase Chain Reaction (PCR) >
        • Infrared PCR
        • Microwave PCR
      • Label-Free Optical Methods for DNA and Cell Quantification
      • DNA Extraction and PCR Amplification
    • Fluidic Control >
      • Passive Valving
    • Genetic Analysis >
      • A Fully Integrated Microfluidic Genetic Analysis Device for the Detection of Blood Cancers
      • Electric Field-Flow Fractionation for DNA Concentration
      • Acousto-Optic Tunable Fiber
    • Narcotics and Explosives Colorimetric Detection
  • People
  • Publications
  • Collaborators
  • Contact
  • Conferences