UNIVERSITY OF VIRGINIA
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        • Enhanced Sperm Cell Recovery
        • Monolith Stationary Phase for Microfluidic DNA Purification
        • Nucleic Acid Purification in a Two-Stage, Dual-Phase Microchip
        • Large Volume Reduction Solid Phase Extraction
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      • Label-Free Optical Methods for DNA and Cell Quantification
      • DNA Extraction and PCR Amplification
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      • A Fully Integrated Microfluidic Genetic Analysis Device for the Detection of Blood Cancers
      • Electric Field-Flow Fractionation for DNA Concentration
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Large Volume Reduction Solid Phase Extraction 

Often times in forensic cases large volumes are required to elute or solubilize a blood sample from various surfaces including clothing and walls. In contrast, microdevices are characterized by small sample volumes.  This raises the need for a sample processing step that would reduce the volume of the forensic sample, providing both a crude purification and sample concentration effect.  These investigations focus on a volume reduction microdevice utilizing various solid phases including chitosan-coated-silica particles (charge switch binding) and magnetic silica particles (hydrogen bonding).  A comparison of the extraction efficiency of the two phases will be investigated, in addition to optimizing the integration with a second, silica based SPE step.  Later work will also involve integration with other processing steps including PCR, ME, and fluorescence detection. 

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Contact Landers Research Group
jpl5e@virginia.edu
(434) 243-8658
375, 379, 395 Chemistry Building
McCormick Road
​Charlottesville, Va 22904
UVA Chemistry Department
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  • Home
  • Previous Research
    • Centrifugal Microdevices >
      • PET Chips
    • Clinical Diagnostics and Forensic Analysis >
      • Cell Sorting and Solid Phase Extraction >
        • Acoustic Differential Extraction
        • Isolation of Circulating Tumor Cells
        • Enhanced Sperm Cell Recovery
        • Monolith Stationary Phase for Microfluidic DNA Purification
        • Nucleic Acid Purification in a Two-Stage, Dual-Phase Microchip
        • Large Volume Reduction Solid Phase Extraction
        • Plastic SPE Microdevices
      • Polymerase Chain Reaction (PCR) >
        • Infrared PCR
        • Microwave PCR
      • Label-Free Optical Methods for DNA and Cell Quantification
      • DNA Extraction and PCR Amplification
    • Fluidic Control >
      • Passive Valving
    • Genetic Analysis >
      • A Fully Integrated Microfluidic Genetic Analysis Device for the Detection of Blood Cancers
      • Electric Field-Flow Fractionation for DNA Concentration
      • Acousto-Optic Tunable Fiber
    • Narcotics and Explosives Colorimetric Detection
  • People
  • Publications
  • Collaborators
  • Contact
  • Conferences