Principal Investigator
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James P. Landers, PhD, FRSC
jpl53@virginia.edu Professor of Chemistry Professor of Mechanical Engineering Associate Professor of Pathology Director, Center for Nano-Biosystems Integration Member, UVA Cancer Center Jefferson Scholar Faculty Fellow Fellow of the Royal Society of Chemistry 1991: Canadian Medical Research Fellow, Mayo Clinic 1988: Ph.D. Biochemistry, University of Guelph, Canada 1983: B.S. Biochemistry, University of Guelph, Canada |
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Dr. James Landers is currently Professor of Chemistry and Professor of Mechanical Engineering at the University of Virginia, as well as Associate Professor of Pathology at the University of Virginia Health System. He earned his Bachelor of Science degree in Biochemistry with a minor in Biomedicine and his Ph.D. in Biochemistry from the University of Guelph in Ontario (Canada) in 1984 and 1988, respectively. After a year as a post-doctoral fellow at the Banting Institute at the University of Toronto School of Medicine, as a Canadian Medical Research Council (MRC) Fellow at the Mayo Clinic-Rochester, he studied cancer biology and diagnostics under Thomas Spelsberg, a renowned breast cancer biochemist. He launched and directed Mayo Clinic’s Clinical Capillary Electrophoresis Facility in the Department of Laboratory Medicine and Pathology, developing clinical assays based on capillary electrophoretic technology.
Dr. Landers joined the Chemistry Department at the University of Pittsburgh in 1997, where he forayed into analytical microfluidic systems with the goal of developing the next generation molecular diagnostics platform. This research was bolstered by the move in 1999 to the University of Virginia where access to a dedicated class-100 cleanroom for microchip fabrication allowed for rapid prototyping of microdevices for separations, DNA purification, and DNA amplification. His group was among the first to generate a fully integrated lab-on-a-chip (PNAS 103:19272, 2006), successfully applied to detecting infectious agents in biofluids and cancer diagnostics, and more recently defined new approaches to fluidic control on microchips (NATURE Physics 5:231, 2009). He has authored more than 180 papers and 25 book chapters on topics as diverse as receptor biochemistry, capillary electrophoretic method development, microchip fabrication, forensic DNA analysis and integrated microfluidic systems for application to both the clinical and forensic arenas. In addition, he has recently completed the third in the succession of editions of CRC Press Handbook of Capillary Electrophoresis, with this one extrapolated to microchip electrophoresis and associated microtechniques.
Dr. Landers joined the Chemistry Department at the University of Pittsburgh in 1997, where he forayed into analytical microfluidic systems with the goal of developing the next generation molecular diagnostics platform. This research was bolstered by the move in 1999 to the University of Virginia where access to a dedicated class-100 cleanroom for microchip fabrication allowed for rapid prototyping of microdevices for separations, DNA purification, and DNA amplification. His group was among the first to generate a fully integrated lab-on-a-chip (PNAS 103:19272, 2006), successfully applied to detecting infectious agents in biofluids and cancer diagnostics, and more recently defined new approaches to fluidic control on microchips (NATURE Physics 5:231, 2009). He has authored more than 180 papers and 25 book chapters on topics as diverse as receptor biochemistry, capillary electrophoretic method development, microchip fabrication, forensic DNA analysis and integrated microfluidic systems for application to both the clinical and forensic arenas. In addition, he has recently completed the third in the succession of editions of CRC Press Handbook of Capillary Electrophoresis, with this one extrapolated to microchip electrophoresis and associated microtechniques.
Administrative Assistant
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Patricia White
phw7t@virginia.edu |
Research Scientists
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Dr. Delphine Le Roux
dsl4b@virginia.edu http://www.linkedin.com/in/delphine-le-roux-4899073 Degrees
PhD in Biochemistry and Molecular Biology, with highest honors - University of Versailles - Saint Quentin en Yvelines, Versailles, France M.S. AgroParisTech - Paris Institute of Technology for Life, Food and Environmental Sciences, Paris, France Research Interests
My research focuses on developing rapid microfluidic DNA analysis systems. My work translates the benchtop processes for DNA extraction, amplification and separation/detection to a simple, elegant microfluidic device. The ultimate goal is to create an integrated easy-to-use instrument to allow non-expert to perform DNA analysis at the point of sample collection. Selected Publications
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Postdoctoral Fellows
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Dr. Christopher Birch
cb2xj@virginia.edu https://www.linkedin.com/in/christopher-birch-0800679 Degrees
MCHEM in chemistry with forensic science, University of Hull PhD in microfluidics and molecular diagnostics, Hull York medical school and the Department of Biology Research interests
My research is focused on the development of microfluidic technologies for use in nucleic amplification methodologies in both a forensic and clinical setting. During my PhD, I was involved in developing porous monolithic materials for incorporation into these systems to act as a sample interface between the real world and the microfluidic domain. In addition, these materials were designed for isolating the DNA of both humans and infectious organisms. I am currently working with centrifugal microfluidics, contributing towards a fully-integrated human DNA profiler. The entails the development of individual assays, such as DNA extraction, polymerase chain reaction and separation, and their subsequent integration on an individual microfluidic device. Teaching areas
Analytical chemistry, molecular biology and forensic science. other activities
I am a keen musician and enjoy playing various open mic nights with my guitar. I find it an amazing way to relax at the end of the night and having an audience respond positively to your own music is an unbelievable feeling. I enjoy watching sports, particularly boxing, soccer and football, and often travel to sports events with friends. selected publications
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PhD Candidates
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Charlie Clark
cpc4wg@virginia.edu degrees
PhD, Chemistry, University of Virginia, 2019 (anticipated) B.S. Chemistry, The College of William and Mary, 2014 research interests
Forensic microfluidics, acoustophoretic separations, colorimetric assays, microfluidic mixing, microfluidic valving, clinical microfluidics. other activities
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Anchi Tsuei
at3ae@virginia.edu degrees
MSc, University of Waikato (NZ) BSc(Tech), University of Waikato research interests
Rapid DNA extraction techniques. Forensic DNA analysis, including rapid DNA technologies, differential extraction, touch DNA, direct PCR. Microchip fabrication, fluidics and applications. other activities
Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy 2016 participant International Symposium on Human Identification 2015 poster presentation Conference on National Defense and Intelligence 2015 participant Research Scientist, University of Virginia, 2015. Scientist, Microlab Diagnostics, 2012-2014. Scientist, ZyGEM Corp, 2010-2012. selected publications
patents
Microfluidic Cartridge. Europe 13709628.5. Issued February 22, 2013 |
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Shane Woolf
msw2s@virginia.edu degrees
M.S. Forensic Science, Virginia Commonwealth University, 2016 B.S. Biology and minor in pre-professional Secondary Education, James Madison University, 2007 A.A.S. Physical Therapy, Tidewater Community College, 1996 research interests
Forensic science and biometrics, human identification, microfluidic separations, microchip and microdevice fabrication, analytical and biological chemistry, and the detection of bioweapons, pathogens, and explosives other activities
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Tiffany Layne
trl3ts@virginia.edu degrees
M.S. Forensic Science, Virginia Commonwealth University, 2016 B.S. Forensic Science, Virginia Commonwealth University, 2014 B.S. Biology, Virginia Commonwealth University, 2014 research interests
Forensic DNA analysis, body fluid identification, microfluidics and fabrication, rapid DNA technologies. other activities
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Killian O'Connell
kco4yh@virginia.edu degrees
B.S. Biochemistry and Molecular Biology, Colorado State University, 2015 research interests
Point-of-care diagnostics, personalized medicine, µTAS, bioanalytical chemistry, pathology, computer programming, and genetic engineering. other activities
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Graduate Students
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Jamila Marshall
jsm2dg@virginia.edu Degrees
MSc Chemistry, Clark Atlanta University, 2015 BSc Chemistry (Hons.), Biology minor, University of the West Indies, Cave Hill Campus, Barbados, 2010 Research Interests
Forensic science, microdevice fabrication, microfluidic separations, bioanalytical chemistry, and the detection of opiates, accelerants and biomarkers. Other Activities
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Leah Dignan
lmd4bt@virginia.edu Degrees
B.S. Chemistry, St. Mary's College of Maryland, 2016 Research interests
Forensic chemistry, microfluidic analysis and device fabrication, and the detection of illicit drugs,explosives, and chemical warfare agents. Other activities
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Undergraduate Students
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Sabrina Kim
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Isabella Mighell
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Rachel Moffet
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Major: Biology,
Global Security & Justice Mentor: Shane Woolf |
Major: Biochemistry
Mentor: Charlie Clark |
Major: Biology
Mentor: Shane Woolf |
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Annie Piland
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Alvand Moini
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Christopher Tomley
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Major: Biology
Mentor: Tiffany Layne |
Major: Biomedical Engineering
Mentor: Killian O'Connell |
Major: Biochemistry
Mentor: Leah Dignan |
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Alexandra Markmann
Major: Biochemistry
Mentor: Tiffany Layne Natalie Collins
Major: Biochemistry
Mentor: Shane Woolf |
Liam Spears
Major: Chemistry
Mentor: Charlie Clark George Fairman
Major: Chemistry
Mentor: Killian O'Connell |
Hannah Lewis
Major: Chemistry
Mentor: Shane Woolf Antea Cooper
Major: Biochemistry
& Molecular Genetics Mentor: Anchi Tsuei |
Alumni
Jingyi Li, PhD, Research Scientist
Shannon Krauss, PhD
Jacquelyn DuVall, PhD
Kimberly Jackson, PhD
Hillary Sloan, PhD
Kerui Xu, PhD
Qian Liu, PhD
Yiwen Ouyang, PhD
Ling Huang, PhD
Jian Wen, PhD
Joan Bienvenue, PhD
Lindsay Bazydlo, PhD
Jessica Norris, PhD
Daniel Marchiarullo, PhD
Brian Poe, PhD
Kyudam Oh, Ph.D
Briony C. Strachan, Ph.D
Jenny A. Lounsbury, Ph.D
Jingyi Li, Ph.D
Carmen R. Reedy, Ph.D
Kristin A. Hagan, Ph.D
James M. Karlinsey, Ph.D
Christopher J. Easley, Ph.D
Daniel C. Leslie, Ph.D
Brandon Thompson, PhD, Post-doctoral Fellow
Daniel Nelson, PhD, Post-doctoral Fellow
Francisco Lara, Ph.D, Post-doctoral Fellow
Murali Ghatkesar, Ph.D, Post-doctoral Fellow
Mariana Almeida, Visiting Graduate Student
Juliane Cristina Borba, Visiting Graduate Student
Gabriela Duarte, Ph.D, Visiting Graduate Student
Alexandra Markmann, Undergraduate
Liam Spears, Undergraduate
Kendall Jenkins, Undergraduate
Victoria Holt, Undergraduate
Josh Shield, Undergraduate
Sarah Wychoff, Undergraduate
Jacob Hughes, Undergraduate
Megan Taleg, Undergraduate
Casey Engel, Undergraduate
David Dent, Undergraduate
Morgan Carter, Undergraduate
Michael Do, Undergraduate
Brett A. Melnikoff, Undergraduate
Ibrahim Tora, Undergraduate
Mackenzie Long, Undergraduate
Michelle Sjostrom, Undergraduate
Anne Karlsson, Visiting Undergraduate
Alexis Chernish, Undergraduate
Shannon Krauss, PhD
Jacquelyn DuVall, PhD
Kimberly Jackson, PhD
Hillary Sloan, PhD
Kerui Xu, PhD
Qian Liu, PhD
Yiwen Ouyang, PhD
Ling Huang, PhD
Jian Wen, PhD
Joan Bienvenue, PhD
Lindsay Bazydlo, PhD
Jessica Norris, PhD
Daniel Marchiarullo, PhD
Brian Poe, PhD
Kyudam Oh, Ph.D
Briony C. Strachan, Ph.D
Jenny A. Lounsbury, Ph.D
Jingyi Li, Ph.D
Carmen R. Reedy, Ph.D
Kristin A. Hagan, Ph.D
James M. Karlinsey, Ph.D
Christopher J. Easley, Ph.D
Daniel C. Leslie, Ph.D
Brandon Thompson, PhD, Post-doctoral Fellow
Daniel Nelson, PhD, Post-doctoral Fellow
Francisco Lara, Ph.D, Post-doctoral Fellow
Murali Ghatkesar, Ph.D, Post-doctoral Fellow
Mariana Almeida, Visiting Graduate Student
Juliane Cristina Borba, Visiting Graduate Student
Gabriela Duarte, Ph.D, Visiting Graduate Student
Alexandra Markmann, Undergraduate
Liam Spears, Undergraduate
Kendall Jenkins, Undergraduate
Victoria Holt, Undergraduate
Josh Shield, Undergraduate
Sarah Wychoff, Undergraduate
Jacob Hughes, Undergraduate
Megan Taleg, Undergraduate
Casey Engel, Undergraduate
David Dent, Undergraduate
Morgan Carter, Undergraduate
Michael Do, Undergraduate
Brett A. Melnikoff, Undergraduate
Ibrahim Tora, Undergraduate
Mackenzie Long, Undergraduate
Michelle Sjostrom, Undergraduate
Anne Karlsson, Visiting Undergraduate
Alexis Chernish, Undergraduate
